GRACE Checklist & Principles

GRACE Checklist

The GRACE Checklist is designed to guide the assessment of observational studies of comparative effectiveness in terms of their quality and usefulness for decision-making.

Developed from review of published literature and tested by hundreds of volunteers from around the world, the GRACE Checklist provides a validated tool for screening the quality of observational comparative effectiveness studies.

• Dreyer NA, Velentgas P, Westrich K et al. The GRACE Checklist for Rating the Quality of Observational Studies of Comparative Effectiveness: A Tale of Hope and Caution. Journal of Managed Care Pharmacy 2014;20(3):301-08.
• Dreyer NA, Bryant A, Velentgas P. The GRACE Checklist: A Validated Assessment Tool for High Quality Observational Studies of Comparative Effectiveness. Journal of Managed Care and Specialty Pharmacy, October 2016; 22(10):1107-13.

GRACE Principles

Designed as a set of high-level questions, the GRACE Principles lay out the elements of good practice for the design, conduct, analysis, and reporting of observational CER studies.

The GRACE principles are endorsed by the International Society for Pharmacoepidemiology and supported by a number of professionals and organizations.

• Dreyer NA, Schneeweiss S, McNeil B, et al: GRACE Principles: Recognizing high-quality observational studies of comparative effectiveness. American Journal of Managed Care 2010;16(6):467-471.