| Title |
Treatment |
Disease Area |
Type
of
Decision |
Adherence and Effectiveness
An observational study found that while inhaled corticosteroids were associated with a lower risk of in-patient admissions and emergency room visits for adherent patients, users of oral controllers derived greater benefit from treatment due to increased adherence. (more)
|
Corticosteroids |
Asthma |
 |
Support for Expanded Indication in a Drug
An observational study that found that clozapine reduced suicide risk was used to support an expanded indication. (more)
|
Clozapine |
Schizophrenia |
 |
Support for Modified Label
A pregnancy registry provided data to support a labeling change from Pregnancy Category C (risk cannot be ruled out) to Pregnancy Category B (no evidence of risk in humans). (more)
|
Acyclovir |
Herpes virus infections |
|
Determining Optimal Dose
Data from large linked registries demonstrated that physicians were more likely to administer high-dose corticosteroids for COPD exacerbations, but that low-dose oral corticosteroids were equally effective and had fewer side effects. (more)
|
Corticosteroids |
COPD |
 |
NICE Technology Appraisals
Data are shown describing four NICE technology assessments that used observational studies to evaluate the clinical effectiveness of drugs, in combination with other types of evidence. NICE recommendations are shown. (more)
|
Several |
Several |
|
